Dr. Benjamin Dilberger, M.Sc., Ph.D.

Dilberger

Benjamin Dilberger holds a Master of Science (M.Sc.) and a doctoral degree in nutritional sciences. For his Ph.D. he developed C. elegans as new research tool to investigate brain aging and Alzheimer`s diseases following the mitochondrial cascade hypothesis. In his collaborative project he is closely working with the reserach group of Prof. Wenzel who chaired the professorship in molecular nutrition research. 

Methods: C. elegans cultivation, measurement of mitochondrial membrane potential, ATP,  pyruvate- and lactate- levels, markers of mitochondrial mass; High-Resolution Respirometry (Oxygraph-2k); western blotting, qRT-PCR, EM-microscopy.

Projects: 

  • New intervertebrate models of aging
  • Effects of metabolites from polyphenols on mitochondrial dysfunction in aging

Publications:

Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP.
Polyphenols and Metabolites Enhance Survival in Rodents and Nematodes-Impact of Mitochondria.
Nutrients. 2019 Aug 13;11(8). pii: E1886. [
open access(IF 4.196)

Dilberger B, Baumanns S, Schmitt F, Schmiedl T, Hardt M, Wenzel U, Eckert GP.
Mitochondrial Oxidative Stress Impairs Energy Metabolism, Reduces Stress Resistance and Longevity of C. Elegans.
Oxid Med Cell Longev. 2019:6840540 [open access(IF 4.868)

Reutzel M, Grewal R,  Dilberger B, Silaidos C, Joppe A, Eckert GP.
Cerebral mitochondrial and cognitive function during aging – a longitudinal study in NMRI mice.
Oxid Med Cell Longev. 2020:4060769  [open access(IF 4.868) 

Krabbendam I, Honrath B, Dilberger B, Iannetti E, Branicky R, Meyer T,  Evers B, Dekker F, Koopman W, Beyrath J, Bano D, Schmidt M, Bakker B, Hekim S, Culmsee C, Eckert GP, Dolga A
SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans.
Cell Death & Disease 2020:1(4):263 (IF 5.959)

Dilberger B Baumanns S, Spieth ST,Wenzel U, Eckert GP.
Infertility induced by auxin in px627 Caenorhabditis elegans does not affect mitochondrial functions and aging parameters.
Aging 2020, 12(12):12268-12284. [open access] (IF 5.515)


Presentations at conferences:


© Prof. Dr. Gunter P. Eckert 2018