Maximilian Pohland 

Maximilian.jpg

Maximilian Pohland holds a Master of Science (M. Sc.) in chemistry. For his Ph. D. he is developing and testing new potential drugs against Alzheimer’s disease in the nutritional neuroscience study group in cooperation with Prof. Dr. Manfred Schubert-Zsilavecz, Institute of Pharmaceutical Chemistry, Goethe - Universitiy of Frankfurt. The new compounds have in addition to their dual mechanism of action as PPARγ and γ-secretase modulators positive effects on mitochondrial function. He is doing research with the help of several in vitro and in vivo methods, using cell culture and mouse models of aging.

Methods: measurement of mitochondrial membrane potential, ATP levels, Aβ ELISA, markers of mitochondrial mass; High-Resolution Respirometry (Oxygraph-2k); western blotting.

Projects: 

Publications:

Asseburg H, Schaefer C, Mueller M, Hagl S, Pohland M, Berressem D, Borchielline, M, Plank C, Eckert GP
Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice
NeuroMolecular Med, 2016, 18(3):378-95.

Pohland M, Hagl S, Pellowska M, Wurglics M, Schubert-Zsilavecz M, Eckert GP
MH84 - A novel γ-secretase modulator/PPARγ agonist - improves mitochondrial dysfunction in a cellular model of Alzheimer's disease
Neurochem Res, 2016, 41(1-2):231-42.

Pellowska M, Stein C, Pohland M, Merk D, Klein J, Eckert GP, Schubert-Zsilavecz M, Wurglics M.  Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity
J Pharm Biomed Anal. 2014, 102C:417-424.

M. Guder, M. Pellowska, M. Pohland, B .O. Kolbesen “Ozone chemistry for BEOL resist stripping - A systematic analytical attempt to understand the interaction of O3 with modern DUV-resists”, Solid State Phenomena Vols. 145-146, 311-314, 2009.

A. Lühken, M. Pohland, D. Sgoff, „Die CD-ROM Batterie“, CHEMKON 17,193-194, 2010.

A. Lühken, M. Pohland, "Chemie am Luftballon. Experimente und Modelle zur Gaspermeation.", Praxis der Naturwissenschaften - Chemie in der Schule, 62, 8, S. 10-15, 2013.

Presentations at conferences:
Pohland M, Hagl S, Wurglics M, Schubert-Zsilavecz M, Eckert GP, „Acidic dual γ-secretase modulators/PPARγ agonists improve the mitochondrial dysfunction in a cellular model of Alzheimer’s disease”, poster presentation at the annual meeting of the American society for neuroscience, Washington, USA (2014)

Pohland M, Hagl S, Wurglics M, Schubert-Zsilavecz M, Eckert GP, „Improvement of mitochondrial dysfunction by modulators of the human γ-secretase modulators/PPARγ agonists with a dual mechanism of action”poster presentation at the annual meeting of the German Society for Pharmacy (DPhG), Frankfurt, Germany (2014)

 H. Asseburg, C. Plank, M. Borchiellini., M. Mueller, M. Pohland, D. Berressem, G.P. Eckert, "Polyphenol-rich grape extract protects from mitochondrial dysfunction in PC12-cells and ameliorates memory and motor performance in C57BL/6 mice". Poster presentation at the 8th World Congress on Polyphenols Applications, Lisbon, Portugal, 2014.

Pohland M, Hagl S, Wurglics M, Schubert-Zsilavecz M, Eckert GP, „PPARγ-agonists as modulators of the human γ-secretase”, Posterbeitrag auf Rhine-Main Neurosience Network Biennial meeting - Oberwesel, 2012.

D. Tsvetanova, R. Vos, M. Pohland, K. Vanstreels, A. Franquet, G. Vereecke, P. W. Mertens, M. M. Heyns “Solvent-based Strip of High Dose Ion Implanted Photoresist” , Plasma Etch and Strip in Microelectronics (PESM) - Grenoble, 2010.


© Prof. Dr. Gunter P. Eckert 2017