Stephanie Hagl, Ph.D.

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Stephanie Hagl graduated in biophysics and earned her Ph.D.  in the nutritional neuroscience research group. She tested the neuroprotective potential of the food ingredients rice bran and curcumin to evaluate their potential in preventing mitochondrial dysfunctions occurring during aging and neurodegeneration, e.g. Alzheimer’s Disease. Both food-components were tested in vitro and in vivo, using cell culture and mouse models of aging and Alzheimer’s Disease. Her dissertation was awarded by the Frankfurt Biotech Alliance and honors her outstanding scientific work in the field of the Life Sciences. As post-doc she was responsible for the training of students in the group. Dr. Hagl left the group end of February 2016. 

Awards: Young investigator award of the international society for neurochemistry. Awarded in Singapore frame of the satellite meeting „Nutraceuticals in Neurodegeneration and Aging“ to the 25th  ISN-13th ASPN Bienal Meeting, Cairns 2016. 

Methods: measurement of mitochondrial membrane potential, ATP levels, lipid peroxidation products, markers of mitochondrial mass; High-Resolution Respirometry (Oxygraph-2k); western blotting.

Projects: 

Publications:

Asseburg H, Schaefer C, Mueller M, Hagl S, Pohland M, Berressem D, Borchielline, M, Plank C, Eckert GP
Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice
NeuroMolecular Med, 2016, 18(3):378-95.

Hagl S, Asseburg H, Heinrich MA, Sus N, Blumrich EM, Dringen R , Frank J, Eckert GP
Effects of long-term Rice Bran Extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice
NeuroMolecular Med, 2016 Sep;18(3):347-63. 

Bhatia HS, Baron J, Hagl S, Eckert GP, Fiebich BL
Rice Bran Derivatives Alleviate Microglia Activation: Possible Involvement of MAPK Pathway

J Neuroinflammation, 2016, 13(1)148 [Free Article]

Pohland M, Hagl S, Pellowska M, Wurglics M, Schubert-Zsilavecz M, Eckert GP
MH84 - A novel γ-secretase modulator/PPARγ agonist - improves mitochondrial dysfunction in a cellular model of Alzheimer's disease
Neurochem Res, 2016, 41(1-2):231-42.

Hagl S, Berressem D, Grewal R, Grebenstein N, Frank J, Eckert GP
Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice
Nutr Neurosci, 2016, 19(1):1-10.  [Pubmed Abstract]

Hagl S, Berressem D, Bruns B, Sus N, Frank J, Eckert GP
Beneficial effects of ethanolic and hexanic rice bran extract on mitochondrial function in PC12 cells and the search for bioactive components 
Molecules, 2015, 20(9), 16524-16539 [open access]

Hagl S, Kocher A, Schiborr C, Kolesova N, Frank J, Eckert GP
Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice -  impact on bioavailability
Neurochem Int, 2015, 89:234-42. [Pubmed Abstract]

Kocher A, Hagl S, Schiborr C, Eckert GP,  Frank J.
Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice.
Nutr Food Sci J (NFS Journal), 2015, 1:3-8. [open access]

Hagl S, Grewal R, Ciobanu I, Helal A, Khayyal MT, Muller WE, Eckert GP
Rice Bran Extract compensates mitochondrial dysfunction in a cellular model of early Alzheimer's disease
J Alz Dis 2015, 1;43(3):927-38. [Pubmed Abstract]

Hagl S, Heinrich M, Kocher A, Schiborrb C, Frank J, Eckert GP
Curcumin micelles improve mitochondrial function in a mouse model of Alzheimer`s disease
J Prev Alz Dis (JPAD). 2014, 1(2):80-83 [link to publisher]

Afshordel S*, Hagl S*, Werner D, Rohner N, Kogel D, Bazan N, Eckert GP
Omega-3 Polyunsaturated Fatty Acids improve mitochondrial dysfunction in brain aging - impact of Bcl-2 and NPD-1
Prostaglandins Leukot Essent Fatty Acids. 2015, 92:23-31 [Pubmed Abstract]

*authors contributed equally

Chin D, Hagl S,  Huebbe P, Pallauf K, Grune T, Frank J, Eckert GP, Rimbach G
Adenosine triphosphate concentrations are higher in the brain of APOE3 compared to APOE4 targeted-replacement mice and can be modulated by curcumin

Genes Nutr. 2014, 9(3):397

Hagl S, Asseburg H, Eckert GP
Nutritional approaches for healthy aging of the brain and the prevention of
neurodegenerative diseases
In: Pharma Nutrition - An Overview (Eds. Garssen, J; Folkerts G), Springer, Stuttgart, 2014, ISBN 978-3-319-06150-4 [link to publisher]

Eckmann J, Clemens LE, Eckert SH, Hagl S, Yu-Taeger L, Bordet T, Pruss RM, Muller WE, Leuner K, Nguyen HP, Eckert GP
Mitochondrial Membrane Fluidity is Consistently Increased in Different Models of Huntington Disease: Restorative Effects of Olesoxime
Mol Neurobiol. 2014, 50(1):107-18 [Pubmed Abstract]

Hagl S, Alexa Kocher A, Christina Schiborr C, Eckert S, Ciobanu I, Birringer M, Al-Askary H, Amr Helal A, Khayyal MT, Frank J, Muller WE, Eckert GP.
Rice bran extract protects from mitochondrial dysfunction in guinea pig brains
Pharmacol Res. 2013, 76C:17-27 [Pubmed Abstract]

Eckert GP, Schiborr C, Hagl S, Abdel-Kader R, Muller WE, Rimbach G, Frank J.
Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse - prone 8
Neurochem Int. 2013, 62(5):595-602. 

Scharzkopf T, Hagl S, Eckert GP, Klein J
Neuroprotection by bilobalide in ischemia: Improvement of mitochondrial function
Pharmazie. 2013, 68:584-589

Eckert GP, Renner K, Eckert SH, Eckmann J, Hagl S, Abdel-Kader RM, Kurz C, Leuner K, Muller
Mitochondrial dysfunction – A pharmacological target in Alzheimer`s disease.
Mol Neurobiol. 2012, 46(1): 136-50.    [Pubmed Abstract]

Eckert GP, Chang S, Eckmann J, Copanaki E, Hagl S, Hener U, Müller WE, Kögel D.
Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing
Biochim Biophys Acta. 2011, 1808(1):236-43

Presentations at conferences:

Hagl S, Eckert GP.
"Rice Bran Extract for the Prevention of Alzheimer`s Disease“. Oral presentation at the APSN Satellite Meeting on “Nutraceuticals in Neurodegenerative Diseases and Aging” on 19th – 21st August 2015, at the National University of Singapore.

"Omega-3 fatty acids in neurodegenerative diseases: focus on mitochondria“  (Hagl S, Eckert GP) in the symposium entitled Novel approaches to neuroprotection at the XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIIth International Conference on Quantification of Brain Function with PET  , June 201, Vancouver, Canada.

Hagl S., Berressem D., Grebenstein N., Frank J., Eckert G.P. "Rice Bran Extract Improves Brain Mitochondrial Function In Aging NMRI Mice poster presentation at the annual meeting of the American society for neuroscience, Washington, USA (2014)

Hagl S., Berressem D., Grebenstein N., Frank J., Eckert G.P. "Age-related brain mitochondrial dysfunction is improved by Rice Bran Extract administration in NMRI mice“ poster presentation at the annual meeting of the German Society for Pharmacy (DPhG), Frankfurt, Germany (2014)

Hagl, S.; Asseburg, H., Berressem, D., Eckert, GP. “Curcumin: new formulations to protect mitochondria in the brain” poster presentation at the conference Cell Symposia: Mitochondria - from Signaling to Disease, Lisbon, Portugal (2013)

Hagl, S., Berressem, D., Eckert, GP. “Herbal antioxidants induce mitogenesis and improve mitochondrial function in PC12 cells” oral presentation at the conference Mitochondrial Biochemistry, Physiology and Pathology, Cambridge, UK (2012)

Hagl, S., Eckert, SH., Grebenstein, N., Khayyal, M., Leuner, K., Frank, J., Müller, WE., Eckert, GP. “γ -Oryzanol and Tocotrienol enriched Rice Bran Extract improves mitochondrial function ex vivo ” poster presentation at the 8th Conference of Mitochondrial Physiology and Pathology, Bordeaux, France (2011)



© Prof. Dr. Gunter P. Eckert 2017