Sarah Afshordel

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Sarah Afshordel studied food-chemistry and worked on her Ph.D. thesis on synaptic dysfunction resulting out of altered cholesterol biosynthesis in ageing, different neurodegenerative diseases (e.g. Alzheimers Disease) and cancer. In this context she was clarifying signal transduction pathways and is testing the impact of different pharmaceuticals and  bioactive food-compounds on synaptogenesis. For her research she applied several in vivo and in vitro methods. Sarah finished her lab-work in February 2014. Her doctoral thesis will be finalized soon.

Methods: Western Blot, neurite growth, HPLC-FD

Projects:

Publications:

Afshordel S, Wood WG, Igbavboa U, Muller WE, Eckert GP. Impaired Geranylgeranyltransferase-I Regulation Reduces Membrane-Associated Rho-Protein Levels in Aged Mouse Brain. J Neurochem. 2014, 129(4):732-42.

Afshordel S, Kern B, Clasohm J, König H, Priester M, Weissenberger J, Kögel D, Eckert GP
Lovastatin and Perillyl alcohol Inhibit Glioma Cell Invasion, Migration, and Proliferation – Impact of Ras-/Rho- Prenylation
Pharmacol Res. 2015, 91:69-77 

Afshordel S, Hagl S, Werner D, Rohner N, Kogel D, Bazan N, Eckert GP
Omega-3 Polyunsaturated Fatty Acids improve mitochondrial dysfunction in brain aging - impact of Bcl-2 and NPD-1
Prostaglandins Leukot Essent Fatty Acids. 2015, in press

Marschalek N, Albert F, Afshordel S, Meske V, Eckert GP, Ohm TG.
Geranylgeranyl pyrophosphate is crucial for neuronal survival but has no special 
role in Purkinje cell degeneration in Niemann Pick type C1 disease.

J Neurochem. 2015, in press 


Presentations at conferences:
to follow

© Prof. Dr. Gunter P. Eckert 2017