Research


Methods

We use different in vitro and in vivo models to investigate the effects  of  food and bioactive food ingredients as well as pharmacological substances on physiological and pathological parameters reflecting the situation in the aging brain and in neurodegeneration. In cooperation with partners from nutritional science and medicine, we aim to evaluate our data in human studies. Standard analytical methods are used to determine the composition of food and food ingredients. Molecular, cellular and biochemical methods together with special techniques are used to characterize the biofunctional or pharmacological effects of test substrates. 

The fully equipped laboratories (140 square meter) are located in the Biomedical Research Center Seltersberg (BFS) Schubertstrasse 81, BFS, 35392 Giessen, Germany.

Basic lab methods
Mitochondria
Synapses


 

Main Focus

The main focus of our research activities lies on biochemical mechanisms of age related neurodegenerative diseases and the modulation thereof by food-based prevention and pharmacological intervention.

Mitochondria

Mevalonate Pathway (Cholesterol, Isoprenoids)

Food

Drug


Models

in vitro 

Alzheimer:

  • SH-SY5Y cells
  • SY5Y-Mock cells
  • SY5Y-APP (695) wt cells
  • SY5Y-APPsw cells
  • PC12neo cells
  • PC12sw cells
  • HEK-APPwt cells
  • HEK-APPsw cells
  • C. elegans CL2006


in vivo

aging:   

  • aged NMRI mice
  • aged C57/BL6 mice
  • (SAMP8 and SAMR1 mice)
  • C. elengans N2

Alzheimer‘s disease:

  • Thy1-APP751 SL mice

Lipid-reserach:

  • Dunkin Hartley guinea pigs

Ischemic Stroke:

  • MCAO model using CD-1 mice (in close cooperation with Dr. Jochen Klein)

Behaviour tests:

  • Open field
  • Passive avoidance
  • Social recognition
  • Object recognition
  • Y-maze
  • Rotarod
  • Nesting
  • Enriched Environment
  • Volunteer physical activity 

Collaborators

Francesco Visioli, Madrid, Spain

W. Gibson Wood, Minneapolis, USA

Nicolas Bazan, New Orleans, USA

MariVi Tejada-Simon, Houston, USA

Ling Li, Minneapolis, USA

Shaowu Cheng, Changsha, China

Wei Yi Ong, Singapore

Michael Heinrich, London, UK

Bernd Fiebich, Freiburg, Germany

Jan Frank, Hohenheim, Germany

Clemens Kunz, Gießen, Germany

Sabine Kuntz, Gießen, Germany

Silvia Rudloff, Gießen, Germany

Gerald Rimbach, Kiel, Germany

Kristina Friedland, Mainz, Germany

Jochen Klein, Frankfurt, Germany

Manfred Schubert-Zsilavecz, Frankfurt, Germany

Donat Kögel, Frankfurt, Germany

Johannes Pantel, Frankfurt, Germany

Ulrich Pilatus, Frankfurt, Germany

Michael Göbel, Frankfurt, Germany

Nils H. Schebb, Wuppertal, Germany

Hans Zischka, Munich, Germany


© Prof. Dr. Gunter P. Eckert 2018