Originals

1. Müller WE, Hartmann H, Eckert GP, Eckert A, Eisert S.
Cholesterol affects neuronal calcium signaling.
Nutrition, Metabolism and Cardiovascular Disease.1997, 7: 210-216.

2. Müller WE, Eckert GP, Scheuer K, Cairns NJ, Maras A, Gattaz WF.
Effects of ß-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of Aß1-42 and Aß1-43. 
Amyloid. 1998, 5: 10-15.

3. Müller WE, Eckert GP, Eckert A. 
Piracetam: Novelty in a unique mode of action. 
Pharmacopsychiatry. 1999, 32. (Suppl. I): 2-9. 

4. Eckert GP, Cairns NJ, Müller WE.
Piracetam reverses hippocampal membrane alterations in Alzheimer’s disease. 
J Neural Transm. 1999, 106: 757-761.

5. Eckert GP, Cairns NJ, Maras A, Gattaz WF, Müller WE.
Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer’s Disease.
Dement Geriatr Cogn Disord. 2000, 11: 181-186.

6. Eckert GP, Kirsch C, Müller WE. 
Differential effects of lovastatin treatment on brain cholesterol levels in normal and Apo E-deficient mice.
Neuro Report. 2001, 12: 883-887.

7. Eckert GP, Müller WE.
Effects of hyperforin on the fluidity of brain membranes.
Pharmacopsychiatry. 2001, 34 (Suppl 1): S22-S25.

8. Serdarevic N, Eckert GP, Müller WE.
The effects of extracts from St. John’s Wort and Kava Kava on brain neurotransmitter levels in the mouse.
Pharmacopsychiatry, 2001, 34 (Suppl 1): S134-S136.

9. Eckert GP, Wood WG, Müller WE. 
Effects of aging and β-amyloid on the properties of brain synaptic and mitochondrial membranes.
J Neural Transm. 2001, 108: 1051-1064.

10. Kirsch C, Eckert GP, Müller WE.
Cholesterol attenuates the membrane perturbing properties of β-amyloid peptide.
Amyloid. 2002; 9: 149-159.

11. Eckert GP, Igbavboa U, Müller WE, Wood WG.
Lipid rafts of purified mouse brain synaptosomes prepared with and without detergent reveal different lipid and protein domains.
Brain Res. 2003, 962: 144-150

12. Kirsc h C, Eckert GP, Müller WE. 
Statins affect cholesterol micro-domains in brain plasma membranes.
Biochem Pharmacol. 2003, 65: 843-856.

13. Eckert GP, Kirsch C, Leutz S, Wood WG, Müller WE.
Cholesterol modulates amyloid beta-peptide’s membrane interaction.
Pharmacopsychiatry. 2003, 36: S136-S143.

14. Kirsch C, Eckert GP, Koudinov AR, Müller WE.
Brain cholesterol, statins and Alzheimer`s disease.
Pharmacopsychiatry. 2003, 36: S107-S112.

15. Keller J-H, Karas M, Müller WE, Volmer DA, Eckert GP, Tawab MA, Blume HH, Dingermann T, Schubert-Zsilavecz M.
Determination of hyperforin in mouse brain by rapid high performance liquid chromatography-tandem mass spectrometry
Anal Chem. 2003, 75: 6084 – 6088.

16. Eckert GP, Keller J-H, Jourdan C, Karas M, Volmer DA, Schubert-Zsilavecz M, Müller WE.
Hyperforin modifies neuronal membrane properties in vivo.
Neurosci Letters. 2004, 367: 139-143.

17. Schaffer S, Eckert GP, Müller WE, Grande S, Galli C, Visioli F. 
Hypochlorous acid scavening properties of local Mediterranean plant foods.
Lipids. 2004, 39:1239-1247.

18. Johnson-Anuna LNA, Eckert GP, Keller J-H, Igbavboa U, Franke C, Fechner T, Schubert-Zsilavecz M, Karas M, Müller WE, Wood WG.
Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex.
J Pharmacol Exp Ther. 2005, 312: 786-793.

19. Igbavboa U, Eckert GP, Malo TM, Studniski AE, Johnson LNA, Yamamoto N, Kobayashi M, Fujita SC, Appel TR, Müller WE, Wood WG, Yanagisawa K. 
Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human APOE3 and 4, and by increasing age.
J Neurol Sci. 2005, 229-230: 225-32.

20. Schaffer S, Schmitt-Schillig S, Müller WE, Eckert GP. 
Antioxidant properties of Mediterranean food plant extracts: geographical differences.
J Physiol Pharmacol. 2005, 56 (Suppl 1):115-24.

21. Schaffer S, Schmitt-Schillig S, Eckert GP, Müller WE.
Mediterrane Ernährung - Benefit und wissenschaftliche Grundlagen.
Pharm Ztg. 2005; 21:17-31.

22. Reising K, Meins J, Bastian B, Eckert GP, Müller WE, Schubert-Zsilavecz M, Abdel-Tawab M.
Determination of Boswellic Acids in brain and plasma by high-performance liquid chromatography/tandem mass spectrometry. 
Anal Chem. 2005, 77: 6640-6645.

23. Eckert GP, Wegat T, Schaffer S, Theobald S, Müller WE.
Oxidativer Stress - Apothekenrelevante Messmethoden im Vergleich.
Pharm Ztg. 2006, 151: 2267-2279.

24. Schultz C, Konig HG, Del Turco D, Politi C, Eckert GP, Ghebremedhin E, Prehn JH, Kogel D, Deller T.
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons.
Mol Cell Neurosci. 2006, 33: 68-80.

25. Sleno L, Daneshfar R, Eckert GP, Müller WE, Volmer DA.
Mass spectral characterisation of phloroglucinol derivates hyperforin and adhyperforin
Rapid Comm Mass Spec. 2006, 20: 2641-2648.

26. Raunser S, Haase W. Franke C, Eckert GP, Müller WE, Kühlbrandt W.
Heterogously expressed GLT-1 associates with lipid rafts in ∼200 nm protein-lipid islands.
Biophys J. 2006, 20(18):2641-8.

27. Weber CC, Eckert GP, Müller WE.
Effects of antidepressants on the brain/plasma distribution of corticosterone. Neuropsychopharmacology. 2006, 31: 2443-2448.

28. Franke C, Nöldner M, Abdel-Kader R, Johnson-Anuna LN, Wood WG, Müller WE, Eckert GP.
Bcl-2 upregulation and neuroprotection in Guinea Pig brain following chronic simvastatin treatment.
Neurobiol Dis. 2007, 25(2):438-45.

29. Johnson-Anuna LN, Eckert GP, Franke C, Igbavboa U, Müller WE, Wood WG.
Simvastatin protects neurons from cytotoxicity by upregulating Bcl-2 mRNA and protein. 
J Neurochem. 2007, 101(1):77-86.

30. Meyer Dos Santos S, Weber CC, Franke C, Müller WE, Eckert GP.
Cholesterol: coupling between membrane microenvironment and ABC transporter activity.
Biochem Biophys Res Commun. 2007, 354(1):216-21.

31. Schaffer S, Podstawa M, Visioli F, Bogan P, Müller WE, Eckert GP.
Hydroxytyrosol-rich olive mill waste extract protects brain cells in vitro and ex vivo.
J Agric Food Chem. 2007, 55(13):5043-9.

32. Eckert GP, Vardanian L, Rebeck GW, Burns MP.
Regulation of central nervous system cholesterol homeostasis by the Liver X Receptor agonist TO-901317.
Neurosci Lett. 2007, 423:47-52.

33. Huebbe P, Schaffer S, Jofre-Monseny L, Boesch-Saadatmani C, Minihane AM, Müller WE, Eckert GP, Rimbach G.
ApoE genotype and vitamin E modulate APP metabolism and cell cycle regulation.
Molecular Nutrition & Food Research. 2007, 51:1510-7.

34. Krüger P, Daneshfar R, Eckert GP, Klein J, Volmer DA, Bahr U, Müller WE, Karas M, Schubert-Zsilavecz M, Abdel-Tawab M.
Metabolism of boswellic acids in vitro and in vivo.
Drug Metabolism and Deposition. 2008, 36: 1135-42.

35. Hooff GP, Volmer D, Wood WG, Müller WE, Eckert GP.
Isoprenoid quantitation in human brain tissue. A validated HPLC-fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP).
Anal Bioanal Chem. 2008, 392: 673-80.

36. Peters I, Igbavboa U, Hartig U, Schütt T, Haidari S, Böttner S, Copanaki E, Deller T, Kögel D, Wood WG, Müller WE, Eckert GP.
The interaction of beta amyloid peptide with cellular membranes stimulates its own production
Biochimica Biophysica Acta – Biomembranes. 2009, 1788: 964-72.

37. Eckert GP, Müller WE.
Presenilin 1 modifies neuronal membranes in vivo.
Biochem Biophys Res Commun. 2009, 382: 673-7.

38. Eckert GP, Hooff GP, Igbavboa U, Strandjord DM, Volmer DA, Müller WE, Wood WG. Regulation of brain isoprenoids farnesyl and geranylgeranyl pyrophosphate is altered in male Alzheimer’s disease.
Neurobiol Disease. 2009, 35: 251-7.

39. Zimmermann M, Eckert GP.
Enhanced student experience: an analysis of subjective evaluation and objective learning success after the transformation of a pharmaceutical physiology course.
Advances in Physiology Education. 2010, 34:1-10.

40. Butterick T, Johnson LN, Igbavboa U, Eckert GP, Müller WE, Wood WG.
Simvastatin stimulates production of the anti-apoptotic protein Bcl-2 via endothelin-1 and NFATc3/4 in SH-SY5Y cells.
Mol Neurobiol. 2010, 41(2-3):384-91.

41. Eckert GP, Franke C, Nöldner M, Rau O, Wurglics M, Schubert-Zsilavecz M, Müller WE.
Plant derived omega-3-fatty acids protect mitochondrial function in the brain.
Pharmacol Res. 2010, 61:234-41.

42. Hooff GP, Peters I, Wood WG, Müller WE, Eckert GP.
Modulation of cholesterol, farnesyl- and geranylgeranylpyrophosphate in neuronal SY5Y cells - impact for beta-amyloid production.
Mol Neurobiol. 2010, 41(2-3):341-50.

43. Schiborr C, Eckert GP, Rimbach G, Frank J.
A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection.
Anal Bioanal Chem. 2010, 397 (5):1917-25.

44. Schaffer S, Müller WE, Eckert GP.
Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells.
Pharmacol Res. 2010, 62: 322–327.

45. Hooff GP, Patel N, Wood WG, Müller WE, Eckert GP, Volmer DA. 
A rapid and sensitive assay for determining human brain levels of farnesyl- (FPP) and geranylgeranyl-pyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS.
Anal Bioanal Chem. 2010, 398:1801–1808

46. Schiborr C, Eckert GP, Weißenberger J, Schwamm D, Müller WE, Grune T, Rimbach G, 
Frank J. 
Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake.
Curr Pharm Biotech. 2010, 11(8):861-7.

47. Eckert GP, Chang S, Eckmann J, Copanaki E, Hagl S, Hener U, Müller WE, Kögel D.
Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. 
Biochim Biophys Acta. 2011, 1808(1):236-43.

48. Eckert GP, Schaeffer E, Schmitt A, Maras A, Gattaz WF.
Increased brain membrane fluidity in Schizophrenia.
Pharmacopsychiatry. 2011;44:1-2.

49. Leuner K, Schütt T, Kurz C, Eckert S, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Dröse S, Wittig I, Willem M, Haass C, Reichert AS, Muller WE.
Mitochondria-derived ROS lead to enhanced amyloid beta formation. 
Antioxid Redox Signal. 2012, 16(12):1421-33.

50. Cernescu  M, Stark T, Kalden E, Kurz C, Leuner K, Deller  T, Gobel M, Eckert GP, Brutschy B.
LILBID-MS - A Novel Approach to Precisely Monitor the Oligomerization of the β-Amyloid Peptide.
Anal Chem. 2012, 84 (12): 5276–5284

51. Eckert SH, Eckmann J, Renner-Sattler K, Eckert GP, Leuner K, Muller WE.
Dimebon ameliorates amyloid-β induced impairments of mitochondrial form and function.
J Alzheimer Dis 2012, 31(1):21-32.

52. Hooff GP, Wood WG, Hyun KJ, Igbavboa U, Ong WY, Muller WE, Eckert GP
Brain Isoprenoids Farnesyl Pyrophosphate and Geranylgeranyl Pyrophosphate are Increased in Aged Mice.
Mol Neurobiol. 2012, 46(1):179-85.

53. Paulke A, Eckert GP, Schubert-Zsilavecz M, Wurglics M
Isoquercitrin Provides Better Bioavailability than Pure Quercetin: Comparision of Quercetin Metabolites in Body Tissue and Brain Sections after Six Day Administration of Isoquercitrin and Quercetin.
Pharmazie. 2012, 12:991-996.

54. Eckmann J, Eckert SH, Leuner K, Muller WE, Eckert GP.
Mitochondrial membranes in brain ageing and neurodegeneration.
Int J Biochem Cell Biol. 2013, 45:76-80.

55. Posada-Duque R, Velasquez-Carvajal D, Eckert GP, Cardona-Gomez GP.
Atorvastatin requires geranylgeranyl transferase-I and Rac1 activation to exert neuronal protection and induce plasticity.
Neurochem Int. 2013, 62(4):433-45.

56. Eckert GP, Schiborr C, Hagl S, Abdel-Kader R, Muller WE, Rimbach G, Frank J.
Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse - prone 8.
Neurochem Int. 2013, 62:595-602.

57. Eckert GP, Reik C, Muller WE.
Simvastatin alters membrane cholesterol distribution and beta-amyloid levels in brains of female APP751SL mice.
Pharmazie. 2013, 68:590-594

58. Schwarzkopf T, Hagl S, Eckert GP, Klein J.
Neuroprotection by bilobalide in ischemia: Improvement of mitochondrial function.
Pharmazie. 2013, 68:584-589

59. Schiborr C, Dorothea Schwamm D, Kocher A, Rimbach G, Eckert GP, Frank J.
The senescence-accelerated mouse – prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals.
Pharmacol Res. 2013, 
74C:113-120

60. Hagl S, Alexa Kocher A, Christina Schiborr C, Eckert S, Ciobanu I, Birringer M, Al-Askary H, Amr Helal A, Khayyal MT, Frank J, Muller WE, Eckert GP.
Rice bran extract protects from mitochondrial dysfunction in guinea pig brains.
Pharmacol Res. 2013, 76C:17-27

61. Afshordel S, Wood WG, Igbavboa U, Muller WE, Eckert GP. 
Impaired Geranylgeranyltransferase-I Regulation Reduces Membrane-Associated Rho-Protein Levels in Aged Mouse Brain.
J Neurochem. 2014, 129(4):732-42

62. Eckmann J, Clemens LE, Eckert SH, Hagl S, Yu-Taeger L, Bordet T, Pruss RM, Muller WE, Leuner K, Nguyen HP, Eckert GP.
Mitochondrial Membrane Fluidity is Consistently Increased in Different Models of Huntington Disease: Restorative Effects of Olesoxime.
Mol Neurobiol. 2014, 
50(1):107-18

63. Chin D, Hagl S,  Huebbe P, Pallauf K, Grune T, Frank J, Eckert GP, Rimbach G.
Adenosine triphosphate concentrations are higher in the brain of APOE3 compared to APOE4 targeted-replacement mice and can be modulated by curcumin

Genes Nutr. 2014, 9(3):397

64. Hagl S, Heinrich M, Kocher A, Schiborrb C, Frank J, Eckert GP
Curcumin micelles improve mitochondrial function in a mouse model of Alzheimer`s disease
J Prev Alz Dise. 2014, 
1(2):80-83

65. Hagl S, Grewal R, Ciobanu I, Helal A, Khayyal MT, Muller WE, Eckert GP
Rice Bran Extract compensates mitochondrial dysfunction in a cellular model of early Alzheimer's disease
J Alz Dis 2015, 1;43(3):927-38.

66.Pellowska M, Stein C, Pohland M, Merk D, Klein J, Eckert GP, Schubert-Zsilavecz M, Wurglics M.
Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity
J Pharm Biomed Anal. 2014, 102c:417-424.

67. Afshordel S, Kern B, Clasohm J, König H, Priester M, Weissenberger J, Kögel D, Eckert GP.
Lovastatin and Perillyl alcohol Inhibit Glioma Cell Invasion, Migration, and Proliferation – Impact of Ras-/Rho- Prenylation.
Pharmacol Res. 2015, 91:69-77

68. Marschalek N, Albert F, Afshordel S, Meske V, Eckert GP, Ohm TG.
Geranylgeranyl pyrophosphate is crucial for neuronal survival but has no special role in Purkinje cell degeneration in Niemann Pick type C1 disease.
J Neurochem. 2015, 
133(1):153-61

69. Afshordel S, Hagl S, Werner D, Rohner N, Kogel D, Bazan N, Eckert GP.
Omega-3 Polyunsaturated Fatty Acids improve mitochondrial dysfunction in brain aging - impact of Bcl-2 and NPD-1 like metabolites
Prostaglandins Leukot Essent Fatty Acids (PLEFA). 2015,  91:69-77

70. Doert A, Pilatus U, Zanella F, Müller WE, Eckert GP. 1H- and 13C-NMR Spectroscopy of Thy-1-APPSL Mice Brain Extracts Indicates Metabolic Changes in Alzheimer’s Disease. J Neural Transm (JONT), 2015, 122(4):541-50

71. Kocher A, Hagl S, Schiborr C, Eckert G.P,  Frank J.  Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice
Nutr Food Sci J (NFS Journal), 2015, 1:3-8.

72. Hagl S, Berressem D, Bruns B, Sus N, Frank J, Eckert GP
Beneficial effects of ethanolic and hexanic rice bran extract on mitochondrial function in PC12 cells and the search for bioactive components 
Molecules, 2015, 20(9), 16524-16539 

73. Hagl S, Kocher A, Schiborr C, Kolesova N, Frank J, Eckert GP. Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice -  impact on bioavailability.
Neurochem Int, 
Neurochem Int, 2015, 89:234-42.

74. Clemens LE,  Weber JJ, Wlodkowski TT, Yu-Taeger L, Michaud M, Calaminus C,  Eckert SH, Gaca J, Weiss A, Magg JCD,  Jansson EKH, Eckert GP, Pichler BJ, Bordet T, Pruss RM, Riess O, Nguyen HP. Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.
Brain, 2015, 138(Pt 12):3632-53.

75. Hagl S, Berressem D, Grewal R, Grebenstein N, Frank J, Eckert GP. Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice.
Nutr Neurosci, 2016, 19(1):1-10. 

76. Pohland M, Hagl S, Pellowska M, Wurglics M, Schubert-Zsilavecz M, Eckert GP. MH84 - A novel γ-secretase modulator/PPARγ agonist - improves mitochondrial dysfunction in a cellular model of Alzheimer's disease. 
Neurochem Res, 2016, 41(1-2):231-42.

77. Bhatia HS, Baron J, Hagl S, Eckert GP, Fiebich BL. Rice Bran Derivatives Alleviate Microglia Activation: Possible Involvement of MAPK Pathway.
J Neuroinflammation, 2016, 13(1)148.

78. Hagl S, Asseburg H, Heinrich MA, Sus N, Blumrich EM, Dringen R , Frank J, Eckert GP. Effects of long-term Rice Bran Extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice
NeuroMolecular Med, 
2016 Sep;18(3):347-63. 

79. Asseburg H, Schaefer C, Mueller M, Hagl S, Pohland M, Berressem D, Borchielline, M, Plank C, Eckert GP. Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice.
NeuroMolecular Med, 2016, 18(3):378-95.

80. Berressem D, Koch K, Franke N, Klein J, Eckert GP. Intravenous treatment with a long-chain omega-3 lipid emulsion provides neuroprotection in a murine model of ischemic stroke - a pilot study.
PLoS ONE, 2016;11(11):e0167329.

81. Koch K, Berressem D, Konietzka J, Thinges A, Eckert GP, Klein J.
Hepatic ketogenesis induced by middle cerebral artery occlusion in mice
JAHA, 2017,
in press

82. Ostermann AI, Reutzel M, Hartung N, Franke N,  Kutzner L, Schoenfeld K, Weylandt KH, Eckert GP, Schebb NH. A Diet Rich in Omega-3 Fatty Acids Enhances Expression of Soluble Epoxide Hydrolase in Murine Brain.
Prostaglandins Other Lipid Mediat. 2017,
in press 

83. Stark T, Lieblein T, Pohland M, Kalden E, Freund P, Zangl R, Grewal R, Heilemann M, Eckert GP, Morgner N, Göbel MW. Peptidomimetics That Inhibit and Partially Reverse the Aggregation of Aβ(1-42).
Biochemistry. 2017,
in press


© Prof. Dr. Gunter P. Eckert 2017